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α-interferon and ganciclovir treatment of infectious mononucleosis compared the efficacy of disease

Of : Cen Danyang Xie Rong Zhu Hong-man Xue early
Abstract Objective To compare the α-interferon (α-INF) and ganciclovir (GCV) treatment of children with symptoms of infectious mononucleosis (IM) of the patients. Methods 222 children, IM is divided into GCV treatment group (59 cases),[link widoczny dla zalogowanych], α-INF treatment group (74 cases) and other drugs (ribavirin, etc.) in the treatment group (89 cases), 3 groups of children age, gender, disease duration , the condition there were no significant differences. GCV treatment group give GCV 10 mg / (kg ? d), 1 times / 12 h, intravenous infusion, 7 d later changed to 5 mg / (kg ? d),[link widoczny dla zalogowanych], 1 times / d, intravenous infusion,[link widoczny dla zalogowanych], the total course of treatment 10 ~ 14 d. α-INF group give α-INF 5 万 U / (kg ? d), intramuscular injection of a total course of 10 ~ 14 d. Results GCV treatment group and α-INF treatment group of fever, angina improvement, lymph nodes, liver and spleen began to narrow, atypical lymphocytes recovered to Key words children; infectious mononucleosis syndrome; α-interferon; ganciclovir 【Abstract】 Objective To compare the therapeutic effect of GCV and α-interferon to infectious mononucleosis (IM) in children.Methods 222 patients were divided into the ganciclovir (GCV) treatment group (n = 59), the α-interferon treatment group (n = 74) and the control group (n = 89). Among these three groups there were no differences in age, sex and patients, condition.Children in the GCVgroup were given GCV 10 mg / (kg ? d), q12 h, iv drip for 7 days, then 5 mg / (kg ? d), qd,[link widoczny dla zalogowanych], iv drip, the whole treatment course were 10-14 days.Patients in the α-interferon group were given α-interferon 5 × 10 4 U / (kg ? d), im, for 10-14 days.The control group were given other drugs (ribavirin, etc). Results ① Between the GCV group and the control group, significant difference were found in the shorten of fever duration, the improvement of the angina, the diminution of the lymph node, liver and spleen and the time atypical lymphocyte decreased <10%. And the same results were also found in the comparation between the α-interferon group and the control group.But there was no statistical difference between the GCV group and the α-interferon group. ② In the GCVgroup granulocyte were found in 4pts, 11 pts had fever in the α-interferon group, the side effects were recovered within3-7 days after drug withdrawal.Conclusion Both GCV and α-interferon are effective in the treatment of IM; And they both had no serious side effect in IM treament. 【Key words】 Children; Infectious mononucleosis; Ganciclovir; α-interferon generally believed that the infectious mononucleosis syndrome (infectious mononucleosis,[link widoczny dla zalogowanych], IM) as a self-limited disease, the symptomatic treatment based. But in recent years of follow-up study found that patients with IM, some children with recurrent disease, persistent poor prognosis [1], so early in the IM to give an effective anti-EB virus (EBV) of the drugs is necessary. EBV at home and abroad for the treatment efficacy of several drugs is still controversial, the paper α-interferon (α-INF) and ganciclovir (GCV) treatment of children were compared the efficacy of IM for the further conduct of the disease clinical research important reference. 1 Materials and methods 1.1 ① clinical diagnostic criteria are fever, angina, tonsillitis, swollen lymph nodes, liver, spleen and large (more than 3 of them positive); ② shaped peripheral blood lymphocytes> 10% or the total number of> 1.0 × 10  9 / L; ③ EB virus antibody (VCA-IgM positive acute phase, double serum VCA-IgG titer of more than 4 times higher); ④ serum Heterophile antibody positive (with IM clinical and laboratory findings consistent with 2 to 4 can be diagnosed in one or more IM) [2]. 1.2 treatment group from January 2002 to December 2006 stay at the pediatric hospital, all patients diagnosed with IM 238 cases, of which 16 cases of severe illness, not included in the group, more than 222 patients were divided into GCV treatment group, α-INF group and other drug treatment group. GCV treatment group, 59 patients, aged 8 months to 13 years old, 36 males and 23 females; α-INF treatment group, 74 patients, aged 1 to 12 years old, 49 males and 25 females; other drug treatment group, 89 patients , aged 6 months to 14 years old, 51 males and 38 female. Group 3 patients age, gender, disease duration, disease and so no significant difference. 1.3 3 treatment groups were symptomatic treatment and appropriate use of antibiotics, GCV treatment group GCV (Qianlong Hubei Pharmaceutical Co., Ltd. production, trade name He Puxin) treatment, the dose 10 mg / (kg ? d ), 1 / 12 h, intravenous infusion, 7 d later changed to 5 mg / (kg ? d), 1 times / d, intravenous infusion, the total course of 10 ~ 14 d. α-INF treatment group using the α-INF (Sansei Shenyang Pharmaceutical production, trade name Yin Tefen) treatment, 50,000 U / (kg ? d), intramuscular injection of a total course of 10 ~ 14 d. Treatment group more than other drugs do not have the two drugs, while the use of other antiviral drugs (ribavirin, etc.) treatment.

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